منابع مشابه
The leukotrienes.
This paper reviews the leukotrienes, a new group of biologically active compounds in the metabolism of eicosapolyenoic acids. The leukotrienes are acyclic eicosanoids that arise through the 5-lipoxygenase pathway from eicosatrienoic, eicosatetraenoic, and eicosapentaenoic acid. Of these eicosatetraenoic acid, arachidonic acid, is the most important source of leukotrienes. Leukotriene B4 (LTB4),...
متن کاملLeukotrienes and kidney diseases
PURPOSE OF REVIEW This review will critically highlight the role of leukotrienes as mediators of renal diseases and drug nephrotoxicity. It will also discuss the recently identified mechanism of cysteinyl leukotrienes induction and action, and will propose clinical implementation of these findings. RECENT FINDINGS Since last reviewed in 1994, leukotrienes were shown to mediate drug-associated...
متن کاملAdipocytes Secrete Leukotrienes
Leukotrienes (LTs) are potent proinflammatory mediators, and many important aspects of innate and adaptive immune responses are regulated by LTs. Key members of the LT synthesis pathway are overexpressed in adipose tissue (AT) during obesity, resulting in increased LT levels in this tissue. We observed that several mouse adipocyte cell lines and primary adipocytes from mice and humans both can ...
متن کامل[Prostaglandins and leukotrienes].
Two classes of arachidonic acid derivatives can be formed by two distinct enzyme systems. Cyclo-oxygenases synthesise prostaglandins, prostacyclin and thromboxane A2 which all possess both pro- and anti-inflammatory properties. Lipoxygenases synthesise on the one hand chemotactic factors, the hydroxylated derivatives of arachidonic acid, the most powerful of which is leukotriene B4, and on the ...
متن کاملBiological Actions of Leukotrienes
Leukotrienes are novel mediators derived from arachidonic acid through the 5-lipoxygenase enzyme system. Leukotriene B4 has potent effects on leukocyte function and in vivo induces leukocyte accumulation and changes in vascular permeability and modulates pain responses. Peptidolipid leukotrienes are potent smooth muscle-contracting agents. They may have important cardiovascular actions through ...
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ژورنال
عنوان ژورنال: Journal of Veterinary Internal Medicine
سال: 1989
ISSN: 0891-6640,1939-1676
DOI: 10.1111/j.1939-1676.1989.tb03081.x